Table 1.

Density of ice, protein, and various detergents affects the contrast in different regions of single particle cryo-EM maps of membrane proteins.

Substance	Density (g/ml)	Reference
Amorphous ice	0.94	Mishima et al., 1985
Protein	~1.36	Fischer et al., 2004
Dodecyl maltoside (DDM)	1.19	Timmins et al., 1988
Lauryldimethylamine-oxide (LDAO)	0.882	Timmins et al., 1988
Triton X-100	1.10	Ganong et al., 1989
Octyl glucoside (OG)	1.16	le Maire et al., 2000
3-[(3-Cholamidopropyl)dimethylammonio]-1- propanesulfonate (CHAPS)	1.23	le Maire et al., 2000
Deoxycholic acid	1.29	le Maire et al., 2000
Sodium dodecyl sulfate (SDS)	1.16	le Maire et al., 2000