Table 2.
Characteristics according to weight change grouping in women.
| Weight loss group n = 19 | No weight change group n = 16 | Weight gain group n = 31 | P Value | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | 1 year | Delta Δ | Baseline | 1 year | Delta Δ | Baseline | 1 year | delta Δ | ||
| Weight, (kg) | 81 (4) | 76 (5) | −4 (−17 to 9)† | 74 (4) | 74 (4) | 0 (−12 to 12)† | 77 (3) | 81 (3) | 4 (−5 to 14)† | <0.001 |
| BMI (kg/m2) | 31 (2) | 29 (2) | −2 (−6 to 3)† | 30 (2) | 30 (2) | 0 (−5 to 5)† | 30 (1) | 32 (1) | 2 (−2 to 5)† | <0.001 |
| FEV1 % predicted# | 78 (4) | 84 (4) | 6 (−6 to 18)† | 77 (6) | 78 (7) | 1 (−19 to 20)† | 83 (4) | 81 (4) | −3 (−14 to 8)† | 0.51 |
| FENO (ppb)¶ | 24.8 (12.9 to 47.7) | 25.0 (17.0 to 36.9) | 1.0 (0.5 to 2.0)‡ | 44.5 (22.9 to 86.6) | 34.9 (19.7 to 61.9) | 1.2 (0.6 to 2.9)‡ | 31.8 (21.6 to 46.8) | 23.4 (17.0 to 32.3) | −1.4 (−2.2 to 0.8)‡ | 0.76 |
| Exacerbation rate | 4.5 (0.9) | 3.9 (0.8) | −0.6 (−3.0 to 1.8)† | 3.7 (0.4) | 2.3 (0.6) | −1.4 (−2.9 to 0)† | 3.7 (0.6) | 2.7 (0.5) | −1.1 (−2.6 to 0.5)† | 0.49 |
| Maintenance prednisolone, % | 47 | 42 | 67 | 67 | 56 | 59 | 0.11 | |||
| Prednisolone dose, mg* | 11 (5–40) | 9 (3–20) | −2.6 (−11 to 6)† | 10 (5–20) | 9 (5–20) | −1 (−6 to 4)† | 9 (5–35) | 7 (3–25) | −1 (−5 to 3)† | 0.96 |
| Inhaled corticosteroid dose (ug) | 1874 (257) | 1889 (111) | 15 (−566 to 596)† | 1325 (121) | 1538 (117) | 213 (−130 to 555)† | 1371 (105) | 1439 (105) | 68 (−229 to 365)† | 0.62 |
| JACQ score | 2.6 (0.3) | 2.4 (0.3) | −0.2 (−1.0 to 0.6)† | 2.5 (0.3) | 2.3 (0.2) | −0.2 (−0.9 to 0.6)† | 2.3 (0.2) | 2.2 (0.2) | −0.1 (−0.8 to 0.5)† | 0.96 |
| JACQ score(independent of FEV1 ) | 2.5 (0.3) | 2.4 (0.3) | −0.1 (−1.1 to 0.8)† | 2.3 (0.3) | 2.2 (0.2) | −0.1 (−0.9 to 0.6)† | 2.3 (0.3) | 2.1 (0.2) | −0.1 (−0.8 to 0.6)† | 0.92 |
| Sputum neutrophils (%) | 44 (6) | 65 (5) | 20 (4 to 36)† | 74 (6) | 76 (4) | 2 (−14 to 18)† | 51 (4) | 69 (5) | 18 (4 to 32)† | 0.06 |
| Sputum eosinophils¶ (%) | 6.5 (2.4 to 17.4) | 2.9 (1.2 to 7.0) | −2.2 (−7.9 to 0.9)‡ | 3.4 (1.4 to 8.4) | 4.6 (1.4 to 14.9) | 0.7 (−2.9 to 0.2)‡ | 6.0 (3.2 to 11.2) | 2.6 (1.2 to 5.8) | −2.3 (−6.1 to 0.9)‡ | 0.01 |
BMI: body mass index; FEV1: forced expiratory volume in 1 second; FENO: fraction exhaled nitric oxide, JACQ: juniper asthma control questionnaire score; data presented as mean (SEM) unless otherwise stated. #postbronchodilator; ¶geometric mean [95% CI];†mean (95% CI); ¶mean [range]; BDP equivalent; ~median (IQR); †mean difference (95% confidence interval); and ‡fold change (95% confidence interval).