Table 3.
Characteristics according to weight change grouping in men.
| Weight loss group n = 11 | No weight change group n = 14 | Weight gain group n = 38 | P Value | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| baseline | 1 year | Delta Δ | Baseline | 1 year | Delta Δ | Baseline | 1 year | delta Δ | ||
| Weight, (kg) | 83 (5) | 78 (4) | −5 (−18 to 8) | 86 (5) | 86 (5) | 0 (−15 to 15) | 89 (4) | 95 (4) | 5 (−6 to 16) | <0.001 |
| BMI (kg/m2) | 28 (2) | 27 (1) | −2 (−6 to 3) | 29 (2) | 29 (2) | 0 (−5 to 5) | 29 (1) | 31 (1) | 2 (−1 to 5) | <0.001 |
| FEV1 % predicted# | 80 (6) | 85 (7) | 5 (−15 to 24) | 72 (5) | 72 (5) | 0 (−15 to 15) | 71 (4) | 73 (4) | 2 (−10 to 14) | 0.32 |
| FENO (ppb) ¶ | 19.3 (14.2 to 26.3) | 25.8 (16.1 to 41.2) | 0.7 (−0.4 to 1.5) | 29.4 (17.8 to 48.7) | 27.9 (18.4 to 42.5) | −1.1 (−2.0 to 1.8) | 41.0 (29.6 to 56.8) | 46.7 (35.5 to 61.4) | 0.9 (−1.3 to 0.6) | 0.37 |
| Exacerbation rate | 4.2 (1.0) | 2.4 (0.8) | −1.8 (−4.5 to 0.8) | 2.1 (0.6) | 2.5 (0.7) | 0.4 (−1.5 to 2.3) | 3.9 (0.6) | 2.6 (0.4) | −1.3 (−0.7 to 1.3) | 0.78 |
| Maintenance prednisolone, % | 0.51 | |||||||||
| Prednisolone dose, mg* | 9 (5 to 20) | 14 (5 to 35) | 5 (−5 to 13) | 8 (5 to 20) | 11 (8 to 20) | 3 (−4 to 3) | 9 (5 to 20) | 10 (5 to 35) | 1 (−3 to 5) | 0.75 |
| Inhaled corticosteroid dose (ug) | 1055 (197) | 1345 (197) | 291 (−289 to 871) | 1800 (226) | 1800 (226) | 0 (−657 to 657) | 1558 (110) | 1889 (155) | 332 (−47 to 710) | 0.14 |
| JACQ score | 1.8 (0.4) | 1.9 (0.4) | 0.1 (−1.2 to 1.4) | 2.5 (0.3) | 2.3 (0.3) | −0.2 (−0.5 to 0.2) | 2.1 (0.2) | 2.1 (0.2) | 0.0 (−0.6 to 0.6) | 0.49 |
| JACQ score(independent of FEV1 ) | 1.7 (0.4) | 1.8 (0.4) | 0.1 (−1.2 to 1.4) | 2.2 (0.4) | 2.1 (0.4) | −0.1 (−1.2 to 0.9) | 1.9 (0.2) | 1.9 (0.2) | 0.0 (−0.7 to 0.6) | 0.48 |
| Sputum neutrophils (%) | 72 (4) | 67 (6) | −5 (−21 to 12) | 60 (8) | 70 (9) | 10 (−16 to 36) | 57 (4) | 72 (4) | 15 (4 to 16) | 0.40 |
| Sputum eosinophils¶ (%) | 4.0 (1.7 to 9.6) | 2.9 (1.1 to 8.2) | −1.4 (−4.8 to 0.4) | 4.8 (1.6 to 13.9) | 1.5 (0.4 to 5.5) | −3.1 (−14.9 to 0.6) | 5.8 (3.3 to 10.5) | 3.0 (1.6 to 5.3) | −2.0 (−4.5 to 0.9) | 0.38 |
BMI Body mass index; FEV1: forced expiratory volume in 1 second; FENO: fraction exhaled nitric oxide; JACQ: juniper asthma control questionnaire score; data presented as mean (SEM) unless otherwise stated. #postbronchodilator; ¶geometric mean [95% CI]; †mean (95% CI); ¶mean [range]; BDP equivalent; ~median (IQR); †mean difference (95% confidence interval); and ‡fold change (95% confidence interval).