Table 1.
Immunophenotypic parameters, histology grade and node status by invasive tumor distribution (unifocal, multifocal, and diffuse) in 875 consecutive breast cancer cases, Falun 2005–2009.
| Phenotype | Invasive tumor distribution | Significance level | ||||
|---|---|---|---|---|---|---|
| Unifocal | Multifocal | Diffuse | Total | Unifocal versus multifocal | Unifocal versus diffuse | |
| ER positive | 83.1% (423/509) | 81.8% (256/313) | 97.7% (42/43) | 83.4% (721/865) | P = .7852 | P = .0178 |
| PR positive | 66.3% (331/499) | 64.9% (203/313) | 53.5% (23/43) | 65.1% (557/855) | P = .8289 | P = .1565 |
| HER2 positive | 9.6% (48/501) | 15.2% (48/315) | 4.8% (2/42) | 11.4% (98/858) | P = .0419 | P = .4334 |
| Triple negative | 11.2% (56/499) | 10.5% (33/313) | 2.4% (1/42) | 10.5% (90/854) | P = .9083 | P = .1144 |
| Basal-like | 12.5% (37/296) | 11.3% (22/195) | 3.7% (1/27) | 11.6% (60/518) | P = .6020 | P = .2896 |
| Grade 3 | 22.6% (115/509) | 25.2% (80/318) | 7.0% (3/43) | 22.8% (198/870) | P = .5664 | P = .0245 |
| Node positive | 27.3% (140/513) | 54.2% (173/319) | 55.8% (24/43) | 38.5% (337/875) | P < .0001 | P = .0001 |