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. Author manuscript; available in PMC: 2010 Dec 2.
Published in final edited form as: Open Addict J. 2010 Jan 1;3:76–87. doi: 10.2174/1874941001003010076

Fig. (2). The alcohol training context reinstates alcohol-seeking after extinction in a different context.

Fig. (2)

A) Rats (N=8) were trained to lever press for alcohol in Context A (black bars) and extinguished in Context B (white bars). Twenty-four hours after the last extinction session (Extinction), subjects underwent the first reinstatement test in Context A (Reinstatement Test Day 1). Two and three weeks later, subjects were tested again for reinstatement of the operant response in Context A (Reinstatement Test Days 14 and 21), and in Context B 15 days after the first reinstatement test (Day 15). No reward was delivered for any of the tests. Depicted are mean alcohol lever presses +/− S.E.M. B) A separate group of rats (N=6) was trained to lever press for sucrose in Context A (gray bars) and extinguished in Context B (white bars). Reinstatement was tested as described in (A). Depicted are mean sucrose lever presses +/− S.E.M. * P < 0.01 as compared to extinction and # P < 0.01 as compared to Reinstatement Test Day 15. Adapted from [30] with permission.