Skip to main content
. Author manuscript; available in PMC: 2010 Dec 2.
Published in final edited form as: Open Addict J. 2010 Jan 1;3:76–87. doi: 10.2174/1874941001003010076

Fig. (3). Context-dependent reinstatement of alcohol-seeking depends upon the full configuration of stimuli that comprise the context.

Fig. (3)

A) Mean (+/− S.E.M.) alcohol lever and inactive lever presses during the final 5 days of self-administration (Self-Admin) and during four different reinstatement tests including the full configuration of stimuli of the ethanol context (Full Context), the alcohol context without the olfactory stimulus (No Odor), the olfactory stimulus alone presented in a novel context (Odor Only), and the same Novel context without the olfactory stimulus. The mean responding in the extinction context the last day of extinction before each test is also depicted. No alcohol was delivered during the reinstatement tests, and the order of reinstatement tests was counter-balanced across subjects. N=6. **P<0.001, *P<0.05 as compared to Extinction responding; ##P<0.005, #P<0.05 as compared to reinstatement in the full context. B) Mean (+/−) S.E.M. entries into the alcohol port by the same subjects as in Fig. (4A). Interestingly, there is a significant increase in port entries only during a reinstatement test with the Full Context. **P<0.005, as compared to extinction responding. Adapted from [31] with permission.