FIG. 1.
Motexafin lutetium concentration (average ± SE) extracted from tumor (N = 5) or plasma (N = 3) (panel A). Effects of motexafin lutetium PDT on relative tumor blood flow (panel B) and oxygenation (panel C). Tumor blood flow during PDT (75 mW/cm2, 200 J/cm2) is expressed relative to blood flow in the minute prior to initiating illumination (indicated by vertical line); plots show the average (± SD) relative blood flow from a representative animal among six measured. Tumor oxygenation (average ± SE) was measured at 180 min after PDT (75 mW/cm2, 200 J/cm2) or control light treatment (N = 3 per group). Motexafin lutetium was injected at 10 mg/kg at 180 min prior to tissue collection or light delivery.