Fig. 1.

Effect of EP on I/R-induced translocation of NF-κB. Representative illustration of NF-NF-κB expression in the cytosolic and nuclear fractions of rat ischemic myocardium by Western blotting. Sham + LR, sham-operated rats in which no tightening of the left coronary artery was performed; sham + EP50, sham-operated rats in which 50 mg/kg EP was administered intraperitoneally 1 hour before ischemic insult; I/R + LR, rats in which 4 mL LR was administered intraperitoneally 1 hour before ischemic insult; I/R + EP50, rats in which 50 mg/kg EP was administered intraperitoneally 1 hour before ischemic insult. NF-NF-κB, nucl-ear factor-NF-κB; NE, nuclear extraction; CE, cytosolic extraction; I/R, ischemia/reperfusion; EP, ethyl pyruvate; LR, lactated Ringer's solution. ^*p < 0.05 vs. sham + LR. ^†p < 0.05 vs. sham + EP50. ^‡p < 0.05 vs. I/R + LR.