Table 1.
Parameters | Group 1 | Group 2 | Group 3 | Group 4 | Group 5 |
---|---|---|---|---|---|
TC (mg/dl) | 79.25±0.42 | 203.80±0.49a*** | 162.16±0.45b*** | 143.61±0.49b*** | 73.30±0.33b*** |
TG (mg/dl) | 58.9±0.74 | 135.1±0.37a*** | 115.6±0.42b*** | 109.1±0.51b*** | 55.3±0.19b*** |
HDL-c (mg/dl) | 29.32±0.63 | 15.00±0.41a*** | 16.16±0.80bNS | 16.82±0.28bNS | 17.02±0.21b*** |
LDL-c (mg/dl) | 73.34±0.48 | 179.78±0.97a*** | 142.48±0.48b*** | 125.19±0.41b*** | 65.64±0.63b*** |
VLDL-c (mg/dl) | 11.78±0.54 | 27.01±0.65a*** | 23.52±0.88b* | 21.82±1.02b*** | 11.06±1.03b*** |
Atherogenic index | 2.70±0.54 | 13.58±0.42a*** | 10.03±0.64b*** | 8.53±0.56b*** | 4.30±0.74b*** |
HMG-CoA/Mevalonate ratio | 11.24±0.83 | 3.31±0.12a*** | 5.86±0.34b** | 7.32±0.49b*** | 7.89±0.37b*** |
Body weight (g) | 249.67±4.12 | 327.57±5.89a*** | 284.24±4.43b*** | 269.16±2.72b*** | 233.84±3.44b*** |
Mesenteric fat pad weight (g) | 0.28±0.12 | 0.87±0.29a** | 0.40±0.03b* | 0.31±0.18b** | 0.17±0.08b*** |
Values are mean ± SEM, n=6 animals in each group. Comparisons were made between: a, group I vs. II and b, group II vs. III, IV, and V. Symbols represent statistical significance:
P<0.05,
P<0.01,
P<0.001