Table 1.
Study code | Vehicle in donor compartment | Vehicle in receptor compartment | Penetration enhancer concentration (% w/v) | |
---|---|---|---|---|
PS1 | Distilled water | IPB of pH 7.4 | None | |
PS2 | IPB of pH 7.4 | IPB of pH 7.4 | None | |
PS3 | Distilled water | IPB of pH 7.4 | aDMF (5%) | |
PS4 | Distilled water | IPB of pH 7.4 | bDMSO (5%) | |
PS5 | Distilled water | IPB of pH 7.4 | 2-Pyrrolidone (5%) | |
PS6 | Ethanolic IPB of pH 7.4 (1:9) | IPB of pH 7.4 | None | |
PS7 | Ethanolic IPB of pH 7.4 (1:9) | IPB of pH 7.4 | Turpentine Oil (5%) | |
PS8 | Ethanolic IPB of pH 7.4 (1:9) | IPB of pH 7.4 | Pine Oil (5%) | |
PS9 | Ethanolic IPB of pH 7.4 (1:9) | IPB of pH 7.4 | Menthol (5%) | |
PS10* | Distilled water | IPB of pH 7.4 | None | |
PS11* | IPB of pH 7.4 | IPB of pH 7.4 | None | |
PS12 | Distilled water | IPB of pH 7.4 | DMSO (7.5%) | |
PS13 | Distilled water | IPB of pH 7.4 | DMSO (10%) |
Drug concentration in donor compartment = 200 μg/ml
DMF = Dimethyl Formamide
DMSO = Dimethyl Sulfoxide. Drug concentration in donor compartment = 100 μg/ml