Table 3.
Influence of various penetration enhancers on the permeability of LHCl
| Study code | Penetration enhancer | *Permeability coefficient Kp ×102(cm hr1) | Enhancement factor (E.F.) |
|---|---|---|---|
| PS1 | Distilled water Control-1 | 6.322 (0.013) | 1.00 |
| PS6 | Ethanolic IPB Control-2 | 6.490 (0.019) | 1.00 |
| PS7 | Turpentine (5%) | 7.450 (0.021) | 1.15 |
| PS4 | DMSO (5%) | 7.491 (0.032) | 1.185 |
| PS8 | Pine oil (5%) | 7.018 (0.036) | 1.08 |
| PS9 | Menthol (5%) | 7.183 (0.044) | 1.11 |
| PS5 | 2- Pyrrolidone (5%) | 6.844 (0.052) | 1.08 |
| PS3 | DMF (5%) | 6.422 (0.071) | 1.01 |
*
Results are a mean of triplicate observations. SEM values are given in parenthesis. Control 1 was used for solution codes PS3, PS4, and PS5. Control 2 was used for solution codes PS7, PS8, and PS9.Drug Concentration = 100 μg/ml