Table 2.

Efficacy of adenovirus-transduced MSCs in preclinical tumor models

Ad5/3, Ad5 with chimeric fiber(Ad5+Ad3); Ad5, adenovirus serotype 5; Ad5.pK7, Ad5 with fiber containing polylysine (7 residues); Ad5RGD, Ad5 with integrin binding RGD motif in its fiber; Ad5wt, Ad5 wild type; AxFAEGFP-F/RGD, adenoviral vector carrying humanized variant of Aequoria victoria green fluorescent protein with RGD-mutated fiber under control of a CA promoter; CX3CL1, C-X3-C-motif ligand 1 (Fractalkine); CXCR4, cxc chemokine receptor 4 (Fusin); hMSC, human MSC; I.A., intraarterial; I.C., intracranial injection; IFN-β, Interferon beta; IL-2, interleukin-2; I.P., intraperitoneal injection; I.T., intratumoral injection; I.V., intravenous injection; mMSC, murine MSC; MOI, multiplicity of infection; MSC, mesenchymal stem cells; PBS, phosphate buffered saline; S.C., subcutaneous.