Fig. 3.
p53 status does not affect IGFBP-3 induction by GF deprivation. Subconfluent EPC2-hTERT cells expressing the dominant negative form of p53 (p53R175H) or empty vector-transduced control (puro) cells were subjected to GF deprivation with KBM for the indicated time periods. Expression of IGFBP-3 and p53 in cell lysates was determined by Western blot analysis. β-Actin was used as a loading control. This result was reproducible in at least 2 independent experiments.