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. Author manuscript; available in PMC: 2010 Dec 2.
Published in final edited form as: Cancer Res. 2006 Oct 15;66(20):9878–9885. doi: 10.1158/0008-5472.CAN-05-4157

Figure 3.

Figure 3

The extracellular domains of E-cadherin and TβRII mediate their physical interaction. A, coimmunoprecipitation and Western blot assays reveal physical interaction between FLAG epitope-tagged E-cadherin and TβRII in Ecad and Ecyto cells. B, coimmunoprecipitation of endogenous E-cadherin in parental, Ecad, and Ecyto cells showed that this interaction not only occurs after overexpression of E-cadherin but is also present in parental and Ecyto cells. Furthermore, TβRI is recruited to this complex. C, transduction of a dominant-negative TβRII mutant lacking the cytoplasmic tail identifies the extracellular domain of TβRII to be sufficient to mediate interaction with endogenous E-cadherin and TβRII.