Figure 1.

Macrophage PPARγ expression and activity are deficient and acquisition delayed in CGD mice during peritonitis. WT and CGD mice were injected intraperitoneally with zymosan and lavage performed at the indicated times. Peritoneal F4/80 monocytes/macrophages were counted (A) and stained for intracellular PPARγ (following permeablilization) (B), surface CD36 (C), and surface macrophage mannose receptor (MMR; D). Mean fluorescence intensity (MFI) is shown (B-D). Data represent mean ± standard error (SE); N = 8 mice per time point. *P < .02 compared with WT mice at the respective time points; #P < .03 compared with baseline [B] values for each genotype, respectively.