Table 1.
Genes identified in AML1-ETO modifier genetic screen
| Names of genes | Names of alleles | Molecular function | Effect on AML1-ETO phenotype |
|---|---|---|---|
| Suppressors | Suppression of phenotype | ||
| EcR | EcRKG04522, EcRQ50st | Nuclear receptor | Strong |
| msl-3 | msl-3d01070, msl-31 | Chromatin and RNA binding | Moderate |
| cpo | cpoBG02810 | mRNA binding | Moderate |
| Kr | Kr2 | Transcriptional repressor | Strong |
| E2f | E2f07172 | Transcription factor | Moderate |
| CG5033 | CG5033EY04217 | Ribonucleoprotein binding | Moderate |
| sls | slsKG00981 | Myosin light chain kinase | Strong |
| Sin3A | Sin3A08269, RNAi | Transcriptional corepressor | Moderate |
| Nurf38 | Nurf38k16102, RNAi | Chromatin remodeling | Strong |
| S0279-04 | Unknown | Moderate | |
| Enhancers | Enhancement of phenotype | ||
| wnt4 | wnt4EMS23, wnt4C1 | Ligand of Frizzled receptors | Strong |
| fz | fzJB | Frizzled receptor | Strong |
| Dfz2 | Df(3R)469-2, Dfz2DN | Frizzled receptor | Strong/moderate |
| Rya-R44F | Rya-R44FEY12439 | Calcium ion transport receptor | Moderate |
| Atu | Atus1938 | Transcription cofactor | Strong |
| Pkc53E | Pkc53EEY14093 | Protein kinase C activity | Moderate |
| Bgb | BgbD | CBFβ homolog | Moderate |
| Dsf | dsfMB03062 | Nuclear receptor | Moderate |
| l(2)06496 | l(2)06496k14618 | Component of microtubule | Strong |
| S0429-38 | Unknown | Strong | |
| S1364-03 | Unknown | Strong | |
| S1364-03 | Unknown | Strong |