Table 2.
Odds ratiosa (95% confidence intervals) for the association between antiepileptic refilling and switching and seizure-related outcomes for primary analyses
| No. days in case/control periods | Refill of the same drug, strength and dosage form from the same manufacturerb | Switch between the same drug, strength and dosage form but from different manufacturersc | Refill-adjusted odds ratio for switching | ||
|---|---|---|---|---|---|
| nd | Odds ratio (95% CI) | nd | Odds ratio (95% CI) | Odds ratio (95% CI) | |
| 21 | 116 | 2.31 (1.56–3.44) | 15 | 2.75 (0.88–8.64) | 1.19 (0.35–3.99) |
| 28 | 151 | 2.08 (1.48–2.93) | 19 | 2.17 (0.82–5.70) | 1.04 (0.37–2.90) |
a
In case-crossover studies, odds ratios are inherently adjusted for time-invariant patient factors
b
Includes refilling of brand products and refilling of generic products
c
included switching between brand and generic products, generic and brand products, and two generic products from different manufacturers
d
n represents the number of index events that contributed to the estimation of the odds ratio