Table 1.
Quantitative inhibition of Amplex Red oxidation from senile plaques in tissue sections from mouse brain.
| Treatment | Amplex Red oxidation index (% Control) |
|---|---|
| Control | 100.2±4.3 |
| Ginkgo biloba (1mg/ml) | 53.4±4.2* |
| Ginkgo biloba (0.01 mg/ml) | 82.2±3.9 |
| Trolox (100 µM) | 47.0±5.0* |
| Trolox (10 nM) | 82.5±4.0 |
| PBN (100 µM) | 44.8±1.6* |
| PBN (10 nM) | 86.1±5.0 |
Amplex Red oxidation index derived from Amplex Red-Thioflavin S intensity ratio, resulting from plaque mediated oxidation is expressed as percentage of Control values. Data are representative of 20–98 plaques from 3 animals. Significant differences were determined by one-way ANOVA followed by Tamhane test. ({F6,306=42.086; *p<0.001} vs. Control Group, Ginkgo biloba (0.01 mg/ml), Trolox (10 nM) and PBN (10nM)).