Table 3.
Ginkgo biloba extract (EGb 761), Trolox and α-phenyl-N-tert-butyl nitrone (PBN), on spine density in APPswe/PS1dE9 mice
| Treatment | Spine density (number/µm) |
|---|---|
| Control day 30 | 0.43±0.04 |
| EGb 761 day 30 | 0.44±0.02 |
| Trolox day 30 | 0.48±0.04 |
| Control day 0 | 0.40±0.08 |
| PBN day 0 | 0.37±0.03 |
| Control day 4 | 0.31±0.05 |
| PBN day 4 | 0.40±0.04 |
| Control day 7 | 0.30±0.06 |
| PBN day 7 | 0.39±0.04 |
Ginkgo biloba (EGb 761) (100mg/Kg/day p.o.) and Trolox (210 mg/Kg/day p.o.) had no significant effect on spine density from dendrites located up to 50 µm from senile plaques after 30 days of treatment (30 days: n=13–21 dendrites, {F2,51=0.513; p=0.602}). Data are mean ± standard deviation from 3–5 animals and differences were assessed by one way ANOVA. Similarly no differences were detected between PBN (100mg/Kg/day i.p) and Control treated animals on spine density before the commencement of the treatment (day 0), after 4 (day 4) or after 7 days of treatment (day 7) (n=4–54, dendrites; p=0.9782, p=0.249, p=0.317 respectively). Data are mean ± standard deviation from 3–6 animals and differences were assessed by Student T test