Table 4.
Mean hormone-related symptom scale scores by tamoxifen use, menopausal status, and treatment type
| Total | Tamoxifen Use | Menopausal Status | Treatment Type | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Symptom scale | Mean (SD) |
Use between baseline & 24 mo |
Use at or before baseline only |
No use during study period |
Pre | Post | Surgery Only |
Surgery/ Radiation |
Surgery/ Chemo |
Surgery/ Radiation/ Chemo |
| Vasomotor | 1.6 (1.1) | 1.9 (1.1) | 1.5 (1.1) | 1.3 (1.0) | 1.5 (1.0) | 1.6 (1.1) | 1.4 (1.1) | 1.5 (1.1) | 2.0 (1.2) | 1.9 (1.1) |
| LSM† | 1.8 a*,b*** | 1.5 a* | 1.3 b*** | 1.2 e*** | 1.7 e*** | 1.5 | 1.6 | 1.8 | 1.7 | |
| Urinary Incontinence | 0.9 (1.1) | 1.0 (1.1) | 1.0 (1.1) | 0.8 (1.0) | 0.6 (0.8) | 1.0 (1.1) | 1.0 (1.1) | 0.9 (1.0) | 1.0 (1.0) | 1.0 (1.1) |
| LSM | 1.2 | 1.2 | 1.0 | 1.0 | 1.1 | 1.1 | 1.0 | 1.3 | 1.2 | |
| Cognitive/Mood | 1.1 (0.8) | 1.1 (0.8) | 1.1 (0.8) | 1.0 (0.8) | 1.1 (0.8) | 1.0 (0.8) | 1.0 (0.8) | 1.0 (0.7) | 1.2 (0.9) | 1.2 (0.9) |
| LSM | 1.3 | 1.3 | 1.2 | 1.2 | 1.3 | 1.2 | 1.2 | 1.4 | 1.3 | |
| Vaginal Symptoms | 0.6 (0.7) | 0.7 (0.8) | 0.4 (0.7) | 0.4 (0.6) | 0.6 (0.7) | 0.5 (0.8) | 0.5 (0.7) | 0.5 (0.7) | 0.8 (0.7) | 0.6 (0.8) |
| LSM | 0.8 c**d*** | 0.5 c** | 0.4 d*** | 0.6 | 0.6 | 0.5 | 0.6 | 0.8 | 0.6 | |
| Weight/Appearance | 1.4 (1.1) | 1.5 (1.2) | 1.4 (1.2) | 1.4 (1.1) | 1.5 (1.1) | 1.3 (1.1) | 1.2 (1.1) | 1.3 (1.1) | 1.5 (1.1) | 1.7 (1.2) |
| LSM | 1.6 | 1.6 | 1.5 | 1.4 | 1.6 | 1.4 h** | 1.5 g* | 1.5 f* | 1.8 f*,g*,h** | |
Note: n = 803 for treatment type and for total sample means; 776 for tamoxifen use at 24-month assessment; 731 for menopausal status at 24-month assessment.
Note: Hormone-related symptom scales coded 0-4 with increasing scores indicating more severe symptoms.
Least-squares means (LSM) adjust for age in years at the time symptoms were measured, breast cancer stage at diagnosis, and antidepressant use at 24-month assessment follow-up; n = 776 for tamoxifen use and treatment type; n = 731 for menopausal status.
Pairwise comparisons of LSM that share a common superscript designated by the letters a through h are those that differ significantly from each other: *p < .05; **p < .01; ***p < .001.