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. Author manuscript; available in PMC: 2011 Nov 11.
Published in final edited form as: J Med Chem. 2010 Nov 11;53(21):7699–7708. doi: 10.1021/jm1008743

Scheme 3.

Scheme 3

Synthesis of Protease Inhibitors 28–31a

a Reagents and conditions: (a) SnCl2.2H2O, EtOAc, 70 °C, 3 h; (b) Ac2O, CH2Cl2, rt, 2 h; (c) MeOCOCl, Na2CO3, CH2Cl2, 0 °C to rt, 2 h.