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. Author manuscript; available in PMC: 2011 Oct 22.
Published in final edited form as: Mol Cell. 2010 Oct 22;40(2):205–215. doi: 10.1016/j.molcel.2010.09.027

Figure 4. Timing of mRNA target expression can be modulated by the interplay amongst transcription factors, miRNAs and mRNA targets.

Figure 4

Depending on whether a transcription factor (TF) activates or represses the level of miRNAs and/or mRNA targets, different timing of mRNA target expression results. The assumption is that it takes time for mature miRNAs to accumulate (deplete) upon transcriptional activation (repression) in suppressing (de-repressing) their mRNA targets. On the other hand, the change in the expression of mRNA targets is immediate.