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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Ann Biomed Eng. 2010 Jun 23;38(12):3581–3591. doi: 10.1007/s10439-010-0103-6

FIGURE 1.

FIGURE 1

A pathologist with a pulmonary sub-specialty manually traced the digitized H&E histological sections, resulting in a set of individual tissue type maps (binary images), which can be combined into a single representative image. The tissue type classes identified by the pathologist included cancerous tumor (in both: solid and bronchoalveolar presentations), necrosis, active and inactive fibrotic tissue, red blood cells, and normal tissue. This image segmentation required approximately two and a half hours to complete (original image magnification of 20×).