Table 3. Ranking of the indices of insulin release according to their rank sums.

	Overall ranking(all SNPs tested)			Ranking for detection of GSIS(MTNR1B, HHEX, and CDKAL1 SNPs)			Ranking for detection of ISIS(TCF7L2, WFS1, and KCNQ1 SNPs)
Rank	Parameter	Rank sum (from lsn)	Rank	Parameter	Rank sum (from lsn)	Rank	Parameter	Rank sum (from lsn)
1	AUCInsulin(0-30)/AUCGlucose(0-30)	24*	1	AUCInsulin(0-30)/AUCGlucose(0-30)	7	1	AUCC-Peptide(0-120)/AUCGlucose(0-120)	6
2	CIR	28*	2	CIR	10	2	AUCC-Peptide(0-30)/AUCGlucose(0-30)	9
3	AUCC-Peptide(0-30)/AUCGlucose(0-30)	29*	3	IGI2	13	3	C-Peptide 30 min	14
	AUCC-Peptide(0-120)/AUCGlucose(0-120)	29*	4	First-phase insulin secretion	16	4	IGI1	17
5	IGI2	33*	5	Insulin 30 min	17		AUCInsulin(0-30)/AUCGlucose(0-30)	17
6	IGI1	36*	6	IGI1	19	6	CIR	18
7	C-Peptide 30 min	39	7	AUCC-Peptide(0-30)/AUCGlucose(0-30)	20	7	IGI2	20
8	Insulin 30 min	42*	8	AUCC-Peptide(0-120)/AUCGlucose(0-120)	23	8	AUCInsulin(0-120)/AUCGlucose(0-120)	22
	First-phase insulin secretion	42	9	AUCInsulin(0-120)/AUCGlucose(0-120)	24	9	Insulin 30 min	25
10	AUCInsulin(0-120)/AUCGlucose(0-120)	46	10	C-Peptide 30 min	25	10	First-phase insulin secretion	26
11	DI oral	55		DI oral	25	11	DI oral	30
12	HOMA-β	64	12	HOMA-B	34		HOMA-B	30

^*Significantly different from HOMA-B (p<0.05; Wilcoxon rank sum test). AUC – area under the curve; CIR – cleared insulin response; DI – disposition index; GSIS – glucose-stimulated insulin secretion; HOMA-B – homeostasis model assessment of beta-cell function; IGI – insulinogenic index; ISIS – incretin-stimulated insulin secretion/incretin production; lsn – least significant number; SNP – single nucleotide polymorphism.