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. 2010 Dec 2;5(12):e14194. doi: 10.1371/journal.pone.0014194

Table 4. Association of the fasting- and OGTT-derived indices of insulin release with IVGTT-derived AIR (N = 274).

AIR
Parameter r p
AUCInsulin(0-30)/AUCGlucose(0-30) 0.76 <0.0001
CIR 0.76 <0.0001
IGI2 0.75 <0.0001
First-phase insulin secretion 0.74 <0.0001
IGI1 0.72 <0.0001
AUCC-Peptide(0-30)/AUCGlucose(0-30) 0.72 <0.0001
Insulin 30 min 0.71 <0.0001
DI oral 0.70 <0.0001
AUCInsulin(0-120)/AUCGlucose(0-120) 0.70 <0.0001
C-Peptide 30 min 0.68 <0.0001
AUCC-Peptide(0-120)/AUCGlucose(0-120) 0.67 <0.0001
HOMA-β 0.64 <0.0001

Prior to multiple linear regression analysis, all continuous variables were loge-transformed to approximate normal distribution. In the multiple linear regression models, AIR was chosen as dependent variable, the fasting-/OGTT-derived insulin secretion index as independent variable and gender, age, BMI, and OGTT-derived insulin sensitivity as confounding variables. AIR – acute insulin response; AUC – area under the curve; CIR – cleared insulin response; DI – disposition index; HOMA-B – homeostasis model assessment of beta-cell function; IGI – insulinogenic index; IVGTT – intravenous glucose tolerance test; OGTT – oral glucose tolerance test.