Table 4. Association of the fasting- and OGTT-derived indices of insulin release with IVGTT-derived AIR (N = 274).
AIR | ||
Parameter | r | p |
AUCInsulin(0-30)/AUCGlucose(0-30) | 0.76 | <0.0001 |
CIR | 0.76 | <0.0001 |
IGI2 | 0.75 | <0.0001 |
First-phase insulin secretion | 0.74 | <0.0001 |
IGI1 | 0.72 | <0.0001 |
AUCC-Peptide(0-30)/AUCGlucose(0-30) | 0.72 | <0.0001 |
Insulin 30 min | 0.71 | <0.0001 |
DI oral | 0.70 | <0.0001 |
AUCInsulin(0-120)/AUCGlucose(0-120) | 0.70 | <0.0001 |
C-Peptide 30 min | 0.68 | <0.0001 |
AUCC-Peptide(0-120)/AUCGlucose(0-120) | 0.67 | <0.0001 |
HOMA-β | 0.64 | <0.0001 |
Prior to multiple linear regression analysis, all continuous variables were loge-transformed to approximate normal distribution. In the multiple linear regression models, AIR was chosen as dependent variable, the fasting-/OGTT-derived insulin secretion index as independent variable and gender, age, BMI, and OGTT-derived insulin sensitivity as confounding variables. AIR – acute insulin response; AUC – area under the curve; CIR – cleared insulin response; DI – disposition index; HOMA-B – homeostasis model assessment of beta-cell function; IGI – insulinogenic index; IVGTT – intravenous glucose tolerance test; OGTT – oral glucose tolerance test.