Figure 5. PROTEIN DIVERGENCE is unevenly distributed among GO-Slim categories.
The heatplot shows proportion of 1∶1 orthologous pairs exhibiting Low, Intermediate and High protein divergence in GO-Slim functional categories. Protein divergence was estimated as the proportion of aligned amino acids that differed between the two orthologues and each orthologous pair was categorized as Low, Intermediate or High (Materials and Methods). Only categories whose proportion of each bin differed from expectations based on all orthologous pairs with a p value less than the Bonferroni-adjusted α of 5.26×10−4 are presented. The average expected proportions based on all orthologous pairs are presented at the top of the heatplot.