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. 2010 Dec 2;6(12):e1001013. doi: 10.1371/journal.pcbi.1001013

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Tetzlaff et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Box diagram of the model feedback loop. Variables are membrane potential , calcium concentration , axonal supply and dendritic acceptance , and connectivity between dendrite and axon and the constant homeostatic value . The up and down arrows indicate if a variable is increased/decreased. For details see main text. (B) The mean synaptic density develops comparable to experimental findings in cell cultures (see inset from [24]). Note, time axis has been stretched in the middle. (C) Development of the average axonal supplies and dendritic acceptances. The network model passes through three different developmental phases: the first phase is characterized by a pronounced increase of the dendritic acceptance. During development, the network undergoes a transition (second phase) and finally it reaches a homeostatic equilibrium (third phase) with more axonal supplies than dendritic acceptances. (D) Network activity and calcium concentration change accordingly. At the beginning, activity rises slowly until a transition happens. During the transition, activity reaches its maximum and subsequently decreases to a homeostatic value.

Inline graphic — (A) Box diagram of the model feedback loop. Variables are membrane potential , calcium concentration , axonal supply and dendritic acceptance , and connectivity between dendrite and axon and the constant homeostatic value . The up and down arrows indicate if a variable is increased/decreased. For details see main text. (B) The mean synaptic density develops comparable to experimental findings in cell cultures (see inset from [24]). Note, time axis has been stretched in the middle. (C) Development of the average axonal supplies and dendritic acceptances. The network model passes through three different developmental phases: the first phase is characterized by a pronounced increase of the dendritic acceptance. During development, the network undergoes a transition (second phase) and finally it reaches a homeostatic equilibrium (third phase) with more axonal supplies than dendritic acceptances. (D) Network activity and calcium concentration change accordingly. At the beginning, activity rises slowly until a transition happens. During the transition, activity reaches its maximum and subsequently decreases to a homeostatic value.