Table 1.
Summary of Susceptibility Studies: Mice challenged with 1 ID50 after pre-treatment with test agent or control
| Test Agent administered 12 h before viral challenge | Fraction infected after Test Agent | Fraction infected after PBS Control | P value | Fold-increase in susceptibility | Osmolality (mOsm/kg) |
|---|---|---|---|---|---|
| Methylparaben/propylparaben (0.18%/0.02%) in HEC gel | 19/60 (32%) | 20/60 (33%) | 1 | 374 | |
| Benzyl alcohol (1%) in HEC gel | 26/60 (43%) | 26/60 (43%) | 1 | 338 | |
| Disodium EDTA (0.1%) in HEC gel | 59/90 (66%) | 52/90 (58%) | 0.095 | 2* | 376 |
| Disodium EDTA (0.0186%) in HEC gel | 10/60 (17%) | 14/60 (23%) | 0.49 | 341 | |
| Propylene glycol (10%) in HEC gel | 38/60 (63%) | 33/60 (55%) | 0.46 | 1,770 | |
| Glycerin (10%) in HEC gel | 15/60 (25%) | 23/60 (38%) | 0.17 | 2* | 1,700 |
| Glycerin (30%) in HEC gel | 32/59 (54%) | 20/59 (34%) | 0.04 | 3 | 4,280 |
| GML (5%) in K-Y Warming Jelly | 59/60 (98%) | 28/60 (47%)♦ | < 0.0001 | > 10 | 10,100 |
| K-Y Warming Jelly (neat) | 57/60 (95%) | < 0.0001 | > 9 | 10,300 | |
| GML (5%) colloidal suspension in PBS | 48/60 (80%) | 33/60 (55%) | 0.006 | 5 | 329 |
| Propylene glycol (neat) | 55/60 (92%) | 28/59 (47%)♦ | < 0.0001 | 10 | 9,990 |
| Polyethylene glycol (PEG-8) (neat) | 55/60 (92%) | < 0.0001 | 10 | 5,610 | |
♦ Control for both agents in the adjacent column in a three-arm experiment.
* Fold-increases were calculated for these formulations because of their strong, though not statistically significant, trends toward increased susceptibility.