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. 2010 Nov 12;107(48):20816–20821. doi: 10.1073/pnas.1005888107

Fig. 2.

Fig. 2.

SR-BI reduction increases vascular and hippocampal fibrillar amyloid deposition in the mouse brain. (A and B) Sagittal sections of hippocampus from J20 and J20/SR-BI+/− mice showing amyloid deposition in vessel walls. (C and D) Amyloid deposition in cortical vessels in J20 and J20/SR-BI+/− mice. (Scale bars, 10 μm.) (E) Densitometric analysis of vascular thioflavine-S load revealed increased vascular fibrillar Aβ deposition in J20/SR-BI+/− mice (*P < 0.05). (F and G) Sagittal sections of 11-mo-old J20 and J20/SR-BI+/− hippocampi stained with thioflavine-S or immunostained with an anti-Aβ antibody (I and J). (Scale bar, 200 μm.) (H and K) Percent area covered by thioflavine-S fluorescence (*P < 0.05, n = 12) (H) or Aβ staining [P = N.S. (nonsignificant), n = 12] (K) were quantified in the hippocampus, showing a significant increase in thioflavine-S–positive amyloid deposits.