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NHC-catalyzed reactions of alpha-hydroxy ketoenone
| Entry | R1 = | % yield* | d.r.† | % ee‡ |
| 1 | Ph | 93 | > 20∶1 | 99 |
| 2 | p-BrC6H4 | 93 | > 20∶1 | 99 |
| 3 | p-MeOC6H4 | 92 | > 20∶1 | 99 |
| 4 | 2-furyl | 85 | > 20∶1 | 99 |
| 5 | p-CHOC6H4 | 96 | > 20∶1 | 99 |
| 6 | H | 89 | > 20∶1 | 99 |
*Isolated yield following chromatography.
†Determined by 1H NMR of unpurified reaction mixtures.
‡Determined by SFC analysis on chiral stationary phases. SFC, supercritical fluid chromatography.
