Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
NHC-catalyzed reactions of N-Cbz protected ketoenone
| Entry | R1 = | % yield* | d.r.† | % ee‡ |
| 1 | Ph | 98% | > 20∶1 | 99 |
| 2 | p-BrC6H4 | 98% | > 20∶1 | 99 |
| 3 | p-MeOC6H4 | 79% | > 20∶1 | 99 |
| 4 | 2-furyl | 98% | 20∶1 | 99 |
| 5 | n-C3H7 | 80% | > 20∶1 | 99 |
*Isolated yield following chromatography.
†Determined by 1H NMR of unpurified reaction mixtures.
‡Determined by SFC analysis on chiral stationary phases.
