Table 3.

Michael–Henry reaction to dideoxy-D-mannopyranose derivatives 7^*

Entry	Product	Time (T1, h)	Time (T2, h)	Yield (%) †	ee (%) ‡
1		4	1	51	98
2		4	1	65	96
3		23	1	48	95
4		5	1	57	98
5		7	1	59	96
6 §		20	2	66	93
7 §		5	1	50	96

^*3 (20 mol%) and 2 (0.2 mmol) were reacted with 1 (4 equiv.) in CH₂Cl₂ at 30 °C for T₁, then DBU (50 mol%) was added and reacted for T₂.

^†Yield of isolated product.

^‡Determined by chiral phase HPLC analysis.

^§3 (50 mol%) was used.