Table 2.
Entry | 7 | Base | Product (9) | Yield, % | ee, % |
1 | 7a | 11 | 78 | 89 | |
2 | 7b | 10 | 65 | 89 | |
3 | 7c | 10 | 64 | 94 | |
4 | 7d | 11 | 68 | 94 | |
5 | 7e | 11 | 77 | 86 | |
6 | 7f | 11 | 80 | 85 | |
7 | 7g | 10 | 66 | 86 | |
8 | 7h | 11 | 68 | 85 | |
9 | 7i | 10 | 62* | 92 | |
10 | 7j | 11 | NR | NA |
NA, not applicable; NR, no reaction.
*9ja could not be separated from a minor impurity which coeluted in a variety of solvent systems.