Table 6.
Entry | 18 | Solvent | T1, °C | T2, °C | Product (19) | Yield, % | ee, % |
1 | 18a | THF | 23 | 0 | 60 | 78 | |
2 | 18b | PhMe | 23 | 23 | 50 | 98 | |
3 | 18b | PhMe | 110 | 110 | 19b | 50 | 89 |
4 | 18b | CH2CI2 | 23 | 23 | 19b | 59 | 96 |
Entry | 18 | Solvent | T1, °C | T2, °C | Product (19) | Yield, % | ee, % |
1 | 18a | THF | 23 | 0 | 60 | 78 | |
2 | 18b | PhMe | 23 | 23 | 50 | 98 | |
3 | 18b | PhMe | 110 | 110 | 19b | 50 | 89 |
4 | 18b | CH2CI2 | 23 | 23 | 19b | 59 | 96 |