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. 2010 Jul 12;107(48):20652–20654. doi: 10.1073/pnas.1003597107

Table 3.

Catalytic asymmetric γ-additions of malonate esters to γ-substituted Weinreb allenamides graphic file with name pnas.1003597107figX16.jpg

Entry R1 Yield, %* ee, %
1 Me 71 95
2 n-Pr 66 93
3 (CH2)2Ph 66 94
4 graphic file with name pnas.1003597107figX17.jpg 70 94

All data are the average of two experiments.

*Yield of purified product. Only the E isomer is observed.