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Domain structures of Crk family adaptor proteins. v-Crk is a fusion protein consisting of N-terminal viral Gag sequences fused to cellular CrkI. CrkI consists of one SH2 and one SH3 domain (nSH3), while CrkII has an additional C-terminal SH3 domain (cSH3). Domain structure of CrkL is similar to CrkII. Tyr 221 and 207 can be phosphorylated by Abl family tyrosine kinases, leading to inhibition of binding activity.
