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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: J Neurochem. 2010 Nov 19;115(6):1530–1542. doi: 10.1111/j.1471-4159.2010.07059.x

Figure 4. The EETs antagonist 14,15-EEZE blocks evoked substance P release from trigeminal ganglion neurons.

Figure 4

Rat primary TGNs (day 4 in culture) were stimulated for 1 hr with capsaicin (CAP, 100 nmol/L), then the media were assayed for substance P release by ELISA. 30 min pre-treatment with the EETs antagonist 14,15-EEZE (10 μmol/L) blocked capsaicin-stimulated substance P release (*P < 0.05, t-test, treatment vs. capsaicin alone; n=4). Capsaicin stimulation was carried out in the continued presence of 14,15-EEZE.