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. Author manuscript; available in PMC: 2010 Dec 2.
Published in final edited form as: Thromb Haemost. 2010 Sep 13;104(6):1116–1123. doi: 10.1160/TH10.1160/TH10-03-0186

Figure 6. Hemostatic parameters are not changed by NP2.

Figure 6

(A) Bleeding effect by transection model. PBS (control), NP2 (80 or 400 µg/kg) or heparin (1 mg/kg) was administered i.v. and allowed to circulate for 15 min. Blood loss was determined as a function of hemoglobin in water (A540 nm), as described in the material and methods section. Data are reported as mean ± SE. Asterisk, P < 0.01, as compared to values observed in control group. (B) Ex vivo aPTT. PBS (control), NP2 (400 µg/kg) or heparin (1 mg/kg) was administered i.v. and allowed to circulate for 30 min. Blood collection, plasma preparation and aPTT measurement were performed as described in the Material and methods section.