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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: J Pathol. 2010 Oct 21;223(2):262–273. doi: 10.1002/path.2789

Table 1.

Notch1/Fbw7 Mutational Status and Clinical Outcome in T-LL

Reference Patient Group Notch1
Mutations		 Fbw7
Mutations		 Wild
Type		 Association with
Outcome
[34] Children (n = 96) 56% N.A. 44% None
[35] Adults (n = 141) 62% 24% 28% Positive (better event free survival and overall survival)
[36] Children (n = 157) 52% N.A. 48% Positive (better early treatment response and long-term outcome)
[37] Children (n = 47) 34% 11% 62% None
[38] Adults (n = 88) 60% 18% 34% None
[39] Children (n = 69) 33% 16% 42% Favourable (better event free survival and overall survival)
[130] Children (n = 70) 57% N.A. 43% None
[41] Children and adults (n = 77) 38% N.A. 62% Unfavourable (higher blast counts in the peripheral blood, worse overall survival)
[71] Children (n = 26) 31% 31% 54% Favourable (better overall survival)