Table 2.
A detailed comparison of the key features in our study compared to that of Thompson et al. [3]
| Parameters | Thompson et al. [3] | Our study |
|---|---|---|
| General parameters | ||
| Number of cases | 187 | 103 |
| Site | Larynx only | All head neck mucosal sites |
| Median age (years) | 66 | 53 |
| M:F | 13:1 | 3.7:1 |
| Pathological features | ||
| Squamoid differentiation | 149 (79.6%) | 48 (46.6%) |
| Polypoid configuration | 185 (98.9%) | 92 (89.3%) |
| Ulcerated | 144 (77%) | 95 (92.2%) |
| Pattern—fasciculated/storiform | 132 (70.5%) | 69 (71.2%) |
| Tumor giant cells | 106 (56.7%) | 46 (44.7%) |
| Stroma—collagen | 93 (49.7%) | 50 (48.5%) |
| Stroma—myxoid | Not mentioned | 35 (34%) |
| Necrosis | 26 (13.9%) | 23 (22.4%) |
| Anaplasia (2+/3+) | 114 (70%) | 96 (93.2%) |
| Atypical mitosis | 171 (91.4%) mean 11.9/10 hpf | 96 (93.2%) (>10/10 hpf) |
| Nucleoli | Not mentioned | 31 (30.1%) |
| Metaplastic component | 13 (7%) | Absent |
| Immunohistochemistry | ||
| Performed in cases | 123 (65.8%) | 82 (79.6%) |
| Epithelial marker positivity | 84 (68.3%) | 55 (53.4%) |
| Pan CK—Intermediate and LMWCK (CK 5, 6, 8, 17, 19) | Not mentioned as a cocktail | 40/80 (50%) |
| Epithelial membrane antigen | 21/117 (17.9%) | 23/80 (28.8%) |
| P63 | Not mentioned | 9/30 (30%) |
| HMWCK (CK1, 5, 10, 14) | Not mentioned as a cocktail | 7/30 (23.3%) |
| Vimentin | 108/108 (100%) | 29/29 (100%) |
| Calponin | Not mentioned | 8/8 (100%) |
| Smooth muscle actin | 40/123 (32.5%) | 4/25 (16%) |
| S100 protein | 6/123 (4.9%) | 2/30 (6.7%) |
| Desmin | 4/123 (3.3%) | 2/11 (18.2%) |
Cocktail of low molecular weight cytokeratins (LMWCK) and high molecular weight cytokeratins (HMWCK)