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Potency of ENaC-activating TIP peptides and selectivity of effect.
| Active test compound | ENaC EC50 (nM) | n | Selectivity | n | |
|---|---|---|---|---|---|
| ENaC (%) | Potassium current (%) | ||||
| TNF-α | 8.2 ± 0.1 | 5 | 93.4 ± 1.9 | 6.9 ± 1.8 | 4 |
| 1 | 54.3 ± 0.8 | 5 | 99.4 ± 0.1 | 0.6 ± 0.1 | 3 |
| 3 | 56.0 ± 0.8 | 4 | 93.4 ± 0.6 | 6.1 ± 0.9 | 3 |
| 4 | 38.3 ± 1.7 | 3 | 99.4 ± 0.2 | 0.6 ± 0.1 | 3 |
| 5 | 45.5 ± 0.6 | 3 | 98.9 ± 0.3 | 1.1 ± 0.3 | 3 |
| 8 | 24.8 ± 0.5 | 5 | 91.2 ± 0.2 | 8.6 ± 0.1 | 3 |
| 9 | 19.9 ± 0.7 | 4 | 89.6 ± 1.2 | 10.4 ± 1.1 | 3 |
