Fig. 3.

Dexamethasone suppressed the serum amyloid A (SAA)-induced p19 and p40 mRNA expressions. Rheumatoid arthritis (RA) synoviocytes were incubated with the indicated concentrations of dexamethasone for 1 h. Cells were then stimulated with 5 µg/ml of SAA for 6 h and IL-23 p19 (a), p40 (b) and glyceraldehyde-3-phosphate dehydrogenase mRNA expression was determined by real-time polymerase chain reaction (PCR). Data are the means of two different RA synoviocytes run in triplicate ± standard deviation. *P < 0·0001 compared to SAA-treated RA synoviocytes.