Fig. 5.

Effects of intravenous (i.v.) immunoglobulin G (IVIgG) on airway inflammation in FcγRIIb-deficient mice. (a) The cellular composition of bronchoalveolar fluid (BALF) in wild-type (WT) and FcγRIIb-deficient mice (IIB) are shown. Sensitized mice received IgG/ phosphate-buffered saline (PBS)-administration and challenged with ovalbumin (OVA). *Significant differences (P < 0·05) versus WT OVA/OVA + PBS, †versus IIB naive, ‡versus WT OVA/OVA + 1 mg IgG. (b) Representative histological findings of haematoxylin and eosin (H&E) or periodic-acid Schiff (PAS)-stained lung sections from FcγRIIb-deficient mice challenged with OVA are shown. Scale bar equals 50 µm.