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. 2010 Nov;162(2):337–347. doi: 10.1111/j.1365-2249.2010.04248.x

Fig. 7.

Fig. 7

Th2 cytokines induce production of CCR3 ligands preferentially by colonic epithelial cells. Chemokine production was measured in supernatants from HT-29 and Caco-2 cell lines after 24 h stimulation with a combination of T helper type 1 (Th1) [10 ng/ml of interleukin (IL)-1α, 50 ng/ml of tumour necrosis factor (TNF)-α and 300 U/ml of interferon (IFN)-γ] or Th2 (10 ng/ml of IL-4, 10 ng/ml of IL-10 and 10 ng/ml of IL-13) cytokines. (a) CCL11/eotaxin-1 production by HT-29 (left panel) and Caco-2 (right panel) cell lines; ND, not detected; (b) CCL24/eotaxin-2 production by HT-29 (left panel) and Caco-2 (right panel) cell lines; (c) CCL26/eotaxin-3 production by HT-29 (left panel) and Caco-2 (right panel) cell lines. Each column represents mean ± standard error of the mean of nine separate experiments. *P < 0·05 between normal controls and Th2 cytokines.