Table 1.
Bacterial chemotaxis reactions
| Reaction | Rate (forward) | Rate (reverse) | Description |
|---|---|---|---|
| A2 <-> A2* | Immediate equilibration | (13.2% active) | CheA activation |
| A2p <-> A2*p | Immediate equilibration | (13.2% active) | CheAp activation |
| A2* -> A2*p | 34 s−1 | - | CheA autophosphorylation7,21 |
| Y + A2p -> Yp + A2 | 1 × 108 M−1s−1 | - | Phosphotransfer24 |
| Y + A2*p -> Yp + A2* | 1 × 108 M−1s−1 | - | Phosphotransfer24 |
| Yp + Z2 <=> Z2Yp | 2 × 107 M−1s−1 | 0.5 s−1 | Complex formation |
| Yp + Z2Yp <=> Z2Yp2 | 1 × 107 M−1s−1 | 0.5 s−1 | Complex formation |
| Z2Yp -> Y + Z2 | 5 s−1 | - | CheYp hydrolysis |
| Z2Yp2 -> Y + Z2Yp | 5 s−1 | - | CheYp hydrolysis |
Reactions labeled with `immediate equilibration' are the system's input: Every 10 ms throughout the simulation, the ratio of the two indicated molecular species was adjusted stochastically. The following abbreviations are used: Y, CheY; Yp, CheYp, phosphorylated CheY; A2, CheA dimer, inactive; A2*, CheA dimer, active; A2p, phospho-CheA dimer, inactive; A2*p, phospho-CheA dimer, active; Z2 CheZ dimer; Z2Yp, complex of CheZ and CheYp; Z2Yp2, complex of CheZ and two CheYp.