Table 4.

WT but not G117H/E197Q pBChE protects guinea pigs from nerve agent challenge

Group	pBChE		Agent
	Dose	Time*		Dose		Time*	Survival after challenge†
n	mg/kg	min		μg/kg	× LD50	min	1 h	24 h
WT pBChE (High)
4	26.15	t = 0	GD	56	2	t = 20	4/4	3/4
WT pBChE (Low)
1	10.50	t = 0	GD	56	2	t = 40	1/1	1/1
1	10.50	t = 0	GD	56	2	t = 22 h	0/1	—
G117H/E197Q pBChE (High)
2	26.15	t = 0	GD	56	2	t = 5	0/2	—
2	26.15	t = 0	GD	126	4.5	t = 5	0/2	—
3	26.15	t = 0	VX	18	2	t = 5	0/3	—
2	26.15	t = 0	GB	87	2	t = 5	0/2	—

^*Time of administration.

^†Survivors per total tested.