Table 4.
Group |
pBChE |
Agent |
||||||
Dose | Time* | Dose | Time* | Survival after challenge† | ||||
n | mg/kg | min | μg/kg | × LD50 | min | 1 h | 24 h | |
WT pBChE (High) | ||||||||
4 | 26.15 | t = 0 | GD | 56 | 2 | t = 20 | 4/4 | 3/4 |
WT pBChE (Low) | ||||||||
1 | 10.50 | t = 0 | GD | 56 | 2 | t = 40 | 1/1 | 1/1 |
1 | 10.50 | t = 0 | GD | 56 | 2 | t = 22 h | 0/1 | — |
G117H/E197Q pBChE (High) | ||||||||
2 | 26.15 | t = 0 | GD | 56 | 2 | t = 5 | 0/2 | — |
2 | 26.15 | t = 0 | GD | 126 | 4.5 | t = 5 | 0/2 | — |
3 | 26.15 | t = 0 | VX | 18 | 2 | t = 5 | 0/3 | — |
2 | 26.15 | t = 0 | GB | 87 | 2 | t = 5 | 0/2 | — |
*Time of administration.
†Survivors per total tested.