Fig. 5.

Classification of HB and HCC with a four-miR signature. (A) Cm1 and Cm2 HB subclasses defined by differential expression of four miRs are significantly associated with clinical parameters. Kaplan–Meier analysis shows significant differences in overall survival probability between patients carrying Cm1- and Cm2-type HBs. (B) Unsupervised hierarchical clustering of 241 HCC samples by using the HB four-miR signature identifies two main tumor classes. (C) Cm1 and Cm2 HCC subclasses present significant differences in clinical annotations and overall patient survival.