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. 2010 Nov 8;107(47):20317–20322. doi: 10.1073/pnas.1009563107

Fig. 5.

Fig. 5.

Tetrameric nucleosomes can be directly discriminated in human chromatin. (A) Topography (height) and phase image of MS and LS HeLa bulk chromatin, with red dotted line circling an example of highly folded bulk chromatin with light phase and taller nucleosomes, and blue dotted line circling an example of extended chromatin with smaller nucleosomes and darker phase (B) Height and (C) volume measurements of LS and MS nucleosomes such as those highlighted in blue above yields values consistent with tetramers.