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. 2007 Dec 19;27(51):13968–13976. doi: 10.1523/JNEUROSCI.2808-07.2007

Figure 1.

Figure 1.

N-Acetylcysteine pretreatment prevents escalation of drug intake during daily extended-access cocaine self-administration. a, b, Data depict mean ± SEM daily cocaine intake (mg/kg, i.v.) across 11 maintenance self-administration sessions (a) and difference in intake between days 11 and 1 to illustrate escalation in intake (b). Rats received saline (Sal) or N-acetylcysteine (NAC) (60 mg/kg, i.p.) before daily saline or cocaine (Coc) (1.0 mg/kg, i.v./infusion; 6 h/d) self-administration sessions. The pretreatment/self-administration drug assignments resulted in the following groups: Sal–Sal (N = 19), NAC–Sal (N = 10), Sal–Coc (N = 18), and NAC–Coc (N = 12). Escalation is operationally defined as a significant increase in the number of infusions obtained relative to day 1. *Significant difference from day 1 intake (a) or rats pretreated with saline before saline self-administration training sessions (Sal–Sal) (b); Dunnett's t, p < 0.05. #Significant difference from NAC–Coc rats.