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. 2007 Dec 19;27(51):13968–13976. doi: 10.1523/JNEUROSCI.2808-07.2007

Figure 3.

Figure 3.

Daily N-acetylcysteine prevents cocaine-induced reinstatement without altering cocaine self-administration. a, b, Data are depicted as mean ± SEM number of infusions across daily self-administration sessions (2 h/d) (a) or responses on the active lever during the last three extinction sessions and the test for cocaine-induced reinstatement (b). Group designations refer only to treatments given during self-administration training, at which time rats received saline or N-acetylcysteine (60 mg/kg, i.p.) before self-administering saline or cocaine (0.5 mg/kg, i.v./infusion; 2 h/d). The pretreatment/self-administration drug assignments resulted in four groups: Sal–Sal (N = 14), NAC–Sal (N = 6), Sal–Coc (N = 14), and NAC–Coc (N = 7). Seven days after the last self-administration session, rats underwent daily extinction training in the absence of any drug treatments. This was followed by a test for cocaine-induced (10 mg/kg, i.p.) reinstatement in the absence of N-acetylcysteine treatment. *Significant difference from the last extinction session; Dunnett's t, p < 0.05. #Significant difference from all other groups; Dunnett's t, p < 0.05.